Could this explain why my Glaucoma-affected vision varies so much day to day?
Entering edit mode
7 months ago
tokyodan • 10

This article is very interesting because over the last few years I have been noticing various differences in my eyesight depending on how well I feel physically, meaning how my gut feels (see next paragraph). On some days, when I feel good, I am surprised at how good my eyesight and field of vision are. Then on other days when my gut is acting up, my vision is so weird that I don't even want to use my eyes. How can vision from Glaucoma vary so much day to day.

How I feel day to day varies because I got severe Diverticulosis and it is hard for me to keep from getting Diverticulitis. I can control it a bit via diet but it seems that I usually have a slight case of diverticulitis. And now that I've read this, I think back to 2001 when I wound up in the hospital with my fist case of diverticulitis: that is also about the time that I was diagnosed with Glaucoma.

glaucoma microbiome tmao:trimethylamine-n-oxide TUDCA • 469 views
Entering edit mode
7 months ago
david 4.2k

I don't know if posting here is the same as registering for your email group. It seems more like a forum than an email group. I don't see a specific way to register for an 'email group'.

Yes, you are correct. This question-answer site is similar to a forum. It is not the same as the email discussion group. To join the email discussion group, register at our main site:

You can see a list of all FitEyes resources at this post: List of FitEyes Resources | Ask FitEyes. I know its a little confusing, and I apologize for that.

I can control [my diverticulitis] a bit via diet but it seems that I usually have a slight case of diverticulitis.

What type of diet works best for you?

I assume you already know that several studies show low fiber diets can increase the risk of diverticulitis. Furthermore, high meat intake, low physical activity, and smoking also increase the risk.

How can vision from glaucoma vary so much day to day.

I know many people who experience this. There is definitely a connection between your body's overall state of health and your vision. As you become healthier overall, your risk of all eye problems will decrease. Of course, genetics play a role, but the rule about overall health assisting your eye health always holds true.

I have been noticing various differences in my eyesight depending on how well I feel physically, meaning how my gut feels.

This is not unexpected. For thousands of years, traditional medical systems (such as TCM) have made a connection between overall (systemic) health and eyesight. TCM specifically links the liver to the eyes.

Here's a famous scientific article that was one of the first serious attempts in mainstream medicine to explore this relationship:

A Sick Eye in a Sick Body? Systemic Findings in Patients with Primary Open-angle Glaucoma - Survey of Ophthalmology00034-8/fulltext)


Despite intense research, the pathogenesis of primary open-angle glaucoma (POAG) is still not completely understood. There is ample evidence for a pathophysiological role of elevated intraocular pressure; however, several systemic factors may influence onset and progression of the disease. Systemic peculiarities found in POAG include alterations of the cardiovascular system, autonomic nervous system, immune system, as well as endocrinological, psychological, and sleep disturbances. An association between POAG and other neurodegenerative diseases, such as Alzheimer disease and Parkinson disease, has also been described. Furthermore, the diagnosis of glaucoma can affect the patient's quality of life. By highlighting the systemic alterations found in POAG, this review attempts to bring glaucoma into a broader medical context.

Could this [article on TMAO] explain why my glaucoma-affected vision varies so much day to day?

I don't think it is the full explanation by itself. But if you improve your gut microbiome, you may also improve your TMAO levels and (by multiple mechanisms) improve your glaucoma. You can have your serum TMAO levels tested as part of a blood test, but my guess is that the issue is more broadly related to all aspects of your gut health.

BTW, one of the best ways to reduce your TMAO levels and improve your gut health is to follow a plant-based diet. If you can eliminate all animal proteins & fats, your gut microbiome will begin to optimize.

This is one study that reinforces the understanding of the relationship between the gut and the eye:

Influence of gut microbiota on eye diseases: an overview - PubMed

emerging findings also suggest the existence of a gut-eye axis, wherein gut dysbiosis may be a crucial factor influencing the onset and progression of multiple ocular diseases, including uveitis, dry eye, macular degeneration, and glaucoma. Currently, supplementation with pre- and probiotics appears is the most feasible and cost-effective approach to restore the gut microbiota to a eubiotic state and prevent eye pathologies.

Here's another study that may interest you:

Gut microbiota and derived metabolomic profiling in glaucoma with progressive neurodegeneration - PubMed

This finding suggests the potential role of the gut microbiota and derived metabolites in glaucoma.

Here's a post that may interest you too:

A dietary supplement for neuroprotection found to shut the door on COVID before it can infect our cells (newly published study) | Ask FitEyes

The post above is about TUDCA, which is a natural bile acid. It has neuroprotective properties and has long been of interest to glaucoma researchers. However, TUDCA can also help certain digestive issues, and many people use it to improve their liver health.

Finally, I'll mention that it is possible oral cannabigerol (CBG) may help your diverticulitis and your eyes. Here are some links to posts about CBG:

I mention CBG because it has been reported to help IBS. But also:

Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P - PubMed

Conclusions: Neural control of colon motility is profoundly altered in patients with diverticulitis. Their raised levels of anandamide (an endogenous cannabinoid), apparent desensitisation of the presynaptic neural cannabinoid CB1 receptor, and the SR141716 induced intrinsic response, suggest that endocannabinoids may be involved in the pathophysiology of complications of colonic diverticular disease.


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