Inflammation and oxidative stress play main roles in neurodegeneration. Interestingly, different natural compounds may be able to exert neuroprotective actions against inflammation and oxidative stress, protecting from neuronal cell loss.
Among these natural sources, Cannabis sativa represents a reservoir of compounds exerting beneficial properties, including cannabigerol (CBG), whose antioxidant properties have already been demonstrated in macrophages. Here, we aimed to evaluate the ability of CBG to protect motor neurons against toxicity.
- CBG pre-treatment was able to reduce the loss of cell viability induced by the experimental toxic condition.
- CBG pre-treatment inhibited apoptosis.
- CBG pre-treatment counteracted not only inflammation, but also oxidative stress.
Indeed, immunocytochemistry showed that CBG pre-treatment reduced nitrotyrosine, SOD1 and iNOS protein levels and restored Nrf-2 levels.
All together, these results indicated the neuroprotective effects of CBG, that may be a potential treatment against neuroinflammation and oxidative stress.
Keywords: Cannabis sativa; cannabigerol; neuroinflammation; oxidative stress; phytocannabinoid.
- In Vitro Model of Neuroinflammation: Efficacy of Cannabigerol, a Non-Psychoactive Cannabinoid - PubMed
- PMID: 29986533
- PMCID: [PMC6073490]
- DOI: [10.3390/ijms19071992]
- Free PMC article
- Int J Mol Sci
- 2018 Jul 8;19(7):1992.