Science: CIGTS: The Collaborative Initial Glaucoma Treatment Study
0
Entering edit mode
22 months ago
david 4.2k
@david_fe

The Collaborative Initial Glaucoma Treatment Study: study design, methods, and baseline characteristics of enrolled patients - PubMed

Abstract

Objective: The Collaborative Initial Glaucoma Treatment Study (CIGTS) is a randomized, controlled clinical trial designed to determine whether patients with newly diagnosed open-angle glaucoma (primary, pigmentary, or pseudoexfoliative) are better treated by initial treatment with medications or by immediate filtration surgery.

Design: Randomized, controlled clinical trial.

Participants: A total of 607 patients with open-angle glaucoma were enrolled.

Intervention: Patients randomized to initial medications (n=307) received a stepped regimen of medications to lower intraocular pressure. Those randomized to initial surgery (n=300) underwent trabeculectomy to lower intraocular pressure.

Main outcome measures: Progression in visual field loss constitutes the study's primary outcome variable. Secondary outcomes include health-related quality of life, visual acuity, and intraocular pressure.

Results: Randomized assignment resulted in a balanced distribution between treatment groups for most demographic and clinical measures assessed at enrollment. More males than females were enrolled (55% were males), and a substantial percentage (38.1 %) of enrollees were blacks. Most enrollees (90.6%) were diagnosed with primary open-angle glaucoma; the remainder had either pseudoexfoliative (4.8%) or pigmentary (4.6%) forms of open-angle glaucoma.

Conclusions: Follow-up of this well-characterized group of patients should provide well-rounded guidance, based on both traditional ophthalmic measures and patients' perspectives on their health-related quality of life, on how best to initially treat open-angle glaucoma.

glaucoma CIGTS:Collaborative-Initial-Glaucoma-Treatment-Study • 371 views
ADD COMMENTlink
0
Entering edit mode

This link is available to logged in FitEyes members only:

CIGTS: The Collaborative Initial Glaucoma Treatment Study Full Text PDF download

ADD REPLYlink

Login before adding your answer.

Traffic: 13 users visited in the last hour

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.