Bioidentical hormone replacement therapy does have a place in glaucoma as estrogens are involved in regulating quantity and quality(health) of mitochondria, nitric oxide, calcium regulation, reactive oxygen species, inflammation, and so much more. Supplement hormones that test low is more than nice—it might be helpful in women seeking advantages for long-game glaucoma.
After I read an article this morning on a substance post, I felt compelled to share. “Estrogen protects mitochondria from oxidative damage. (Mitochondria: Target organelles for estrogen action. Postepy Hig Med Dosw (Online). 2017 Jun 8;71(0):454-465)” Here is the abstract: Mitochondria: Target organelles for estrogen action
Małgorzata Chmielewska 1 , Izabela Skibińska 1 , Małgorzata Kotwicka 1 Affiliations expand PMID: 28665276 DOI: 10.5604/01.3001.0010.3828 Free article Abstract
Estrogens belong to a group of sex hormones, which have been shown to act in multidirectional way. Estrogenic effects are mediated by two types of intracellular receptors: estrogen receptor 1 (ESR1) and estrogen receptor 2 (ESR2). There are two basic mechanisms of estrogen action: 1) classical-genomic, in which the ligand-receptor complex acts as a transcriptional factor and 2) a nongenomic one, which is still not fully understood, but has been seen to lead to distinct biological effects, depending on tissue and ligand type. It is postulated that nongenomic effects may be associated with membrane signaling and the presence of classical nuclear receptors within the cell membrane. Estrogens act in a multidirectional way also within cell organelles. It is assumed that there is a mechanism which manages the migration of ESR into the mitochondrial membrane, wherein the exogenous estrogen affect the morphology of mitochondria. Estrogen, through its receptor, can directly modulate mitochondrial gene expression. Moreover, by regulating the level of reactive oxygen species, estrogens affect the biology of mitochondria. The considerations presented in this paper indicate the pleiotropic effects of estrogens, which represent a multidirectional pathway of signal transduction.“ [end of abstract ]
The article shared below has over 100 citations that also contain helpful insights. Until researchers can connect glaucoma with overall mitochondrial optimal health, we must seek optimal body functioning on our own. There is no single exercise routine, way of eating, or set of supplements that lead us to optimal body functioning. It is an all of the above—everything that makes our bodies function at their best can be a factor in addressing and even modifying glaucoma - its progression and damages.
https://phmd.pl/resources/html/article/details?id=152495&language=en
Abstract Estrogens belong to a group of sex hormones, which have been shown to act in multidirectional way. Estrogenic effects are mediated by two types of intracellular receptors: estrogen receptor 1 (ESR1) and estrogen receptor 2 (ESR2). There are two basic mechanisms of estrogen action: 1) classical-genomic, in which the ligand-receptor complex acts as a transcriptional factor and 2) a nongenomic one, which is still not fully understood, but has been seen to lead to distinct biological effects, depending on tissue and ligand type. It is postulated that nongenomic effects may be associated with membrane signaling and the presence of classical nuclear receptors within the cell membrane. Estrogens act in a multidirectional way also within cell organelles. It is assumed that there is a mechanism which manages the migration of ESR into the mitochondrial membrane, wherein the exogenous estrogen affect the morphology of mitochondria. Estrogen, through its receptor, can directly modulate mitochondrial gene expression. Moreover, by regulating the level of reactive oxygen species, estrogens affect the biology of mitochondria. The considerations presented in this paper indicate the pleiotropic effects of estrogens, which represent a multidirectional pathway of signal transduction.
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