22 months ago

lisa.c.liu@gmail.com • 20

@_588

i saw a post about CBG oil can reduce eye pressure. i am wondering what's the dosing for that to begin with? if i am using the 5000mg product that i got from fiteye store? thanks

22 months ago

david 4.3k

@david_fe

i saw a post about CBG oil can reduce eye pressure.

CBG has been shown to reduce IOP in several pre-clinical studies. CBD, on the other hand, has been shown to increase IOP in one study. That study and several others are mentioned at this link:

Various Natural Compounds of Interest In Supporting Healthy Intraocular Pressure | Ask FitEyes

Here are short summaries of the studies related to CBG specifically:

Intraocular pressure, ocular toxicity and neurotoxicity after administration of cannabinol (CBN) or cannabigerol (CBG) | Ask FitEyes

Summary of major points from the scientific publication:

• Marijuana, delta-9-tetrahydrocannabinol (THC) and cannabinol (CBN) produced both ocular toxicity and neurotoxicity.

• Cannabigerol (CBG) completely lacked these toxicities.

• Cannabigerol (CBG) caused a significant reduction in intraocular pressure with consistent administration, and the magnitude of pressure reduction was greater than cannabinol (CBN).

A comparison of the ocular and central effects of delta 9-tetrahydrocannabinol and cannabigerol - PubMed

Neither delta 9-THC nor cannabigerol altered the rate of formation of aqueous humor. On the other hand, both cannabinoids produced a two-to three-fold increase in aqueous outflow facility. These results suggest that cannabigerol and related cannabinoids may have therapeutic potential for the treatment of glaucoma.

Summary: THC and CBG both produce a similar IOP reduction, which is achieved by a two-to three-fold increase in aqueous outflow facility without any alteration in the rate of aqueous humor formation. Aqueous humor nourishes the anterior segment of the eye with nutrients and oxygen (it is like a clear blood in this regard), so maintaining its formation and increasing the outflow to manage intraocular pressure is very positive.

Pharmacological Aspects and Biological Effects of Cannabigerol and Its Synthetic Derivatives - PubMed

Cannabigerol (CBG) is a cannabinoid from the plant Cannabis sativa that lacks psychotomimetic effects.

Pre-clinical findings show that CBG reduces intraocular pressure, possesses antioxidant, anti-inflammatory, and anti-tumoral activities, and has anti-anxiety, neuroprotective, dermatological, and appetite-stimulating effects. Several findings suggest that research on CBG deserves to be deepened, as it could be used, alone or in association, for novel therapeutic approaches for several disorders.

In regard to your question on dosing, you asked:

i am wondering what's the dosing for that to begin with? if i am using the 5000mg product that i got from fiteyes store?

There are no scientific or clinical studies we can look to for a general answer to this question. Also, only your own health care professional can make specific dosage recommendations to you.

CBG is sold as a dietary supplement. As such, it is not offered as a medical treatment for glaucoma. The research suggests it may play a role in supporting healthy intraocular pressure levels. But it is important to note that we cannot legally offer specific dosing advice to you, and we can't offer CBG as a treatment for any medical condition.

I can mention a few facts about this specific product that may help you:

• one full dropper is about 1 milliliter
• one full dropper is about 30 drops
• one full dropper contains about 167 mg of CBG

In the FitEyes email discussion archives there are several threads about CBG dosing where a few people (including me) share doses we have tried. Those are by no means a recommendation of the proper dose for you or any specific individual. Thanks for understanding these limitations.

Re: CBG lowers my IOP! - All - FitEyes Discussion - LOGIN REQUIRED