There are many web pages about Tylenol (also called acetaminophen or paracetamol) lowering the pressure in the healthy and glaucomatous eye.
Intraocular pressure-lowering effect of oral paracetamol and its in vitro corneal penetration properties Clinical Ophthalmology, 02/04/2013 Clinical Article Authors: Mohamed N, Meyer D Published Date January 2013 Volume 2013:7 Pages 219 - 227 DOI: http://dx.doi.org/10.2147/OPTH.S38473
Some researchers use it orally, other intravenous, and other intraperitoneally.
This clinical trial below was conducted by Johns Hopkins but it has no posted results. https://www.mdlinx.com/hospital-administration/clinical-trials/clinical-trial-detail.cfm?nct_id=NCT02366065 Does Oral Acetaminophen Lower Intraocular Pressure?
This is an old patent application for it https://patents.google.com/patent/ES2424872T3/en
Has anybody tried it or found somehow whether this medicine lowers the IOP? If anyone knows, could you please share what you know here? I have not experienced with it.
Thanks for the info, David. Would you mind posting more details of your experiment? Did you take 1000mg at one time? How many points did your IOP drop? How long did the reduction in IOP last? Liver health is a valid concern but I wonder if dandelion and milk thistle could help prevent damage. Most pharmaceutical glaucoma treatments are harmful to the body in one way or another so I haven't taken Tylenol off my list of "maybe someday, if necessary" remedies. Thanks for all your help!
Regular use of Tylenol (also called acetaminophen or paracetamol) is also associated with hearing loss, the hypothesis being that the medication decreases levels of cochlear glutathione (which has been shown to protect the cochlea from noise-induced damage). A couple of studies:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209586/
Duration of Analgesic Use and Risk of Hearing Loss in Women https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831770/
Analgesic Use and the Risk of Hearing Loss in Men
It was not my experiment. This was done by a FitEyes member with a Reichert tonometer. He has done a lot of IOP measuring and experimenting for many years. I know him. He's good at this type of experiment.
His initial report said:
But that was his preliminary report from just 2 days. Later on, his replies were more along the lines of what he said above and what he said other times such as below:
Therefore, my understanding was the the initial positive response from the first two days did not hold up on further testing. If he had consistently gotten a 3-4 mmHg reduction each morning he would have been thrilled and would have said the effect was significant. Instead, he called it "very slight."
I will also say that I am probably not willing to do the experiment. I do not want to take 1000mg+ of Tylenol each day. The risk of hepatotoxicity becomes higher when using it long term.
Also, I think I know the reason for his good results the first two days. Notice the methodology:
The "control" experiment for that would be to wake up, get out of bed for a couple minutes, walk to kitchen or whatever, then go back to sleep for a couple more hours.
Invariably, if you do that, you will find a lower IOP upon final awakening compared to if you had slept through the entire night without getting up. Many, many FitEyes members have reported this effect to me. I've seen it a few times myself too.
I think that's what happened in his first two tests, and it is also why he lost enthusiasm in the results after he tested further.