Palmitoylethanolamide (PEA) is supposed to lower intraocular pressure as much as dorzolamide, brinzolamide 17%–20%, brimonidine 18%–25% or betaxolol 20%–23% with no serious side effects.
This study reported a 3mm+ drop in IOP from using PEA: Ocular Hypotensive Effect of Oral Palmitoylethanolamide: A Clinical Trial | IOVS | ARVO Journals
I gather that PEA is not a cannabinoid, but is chemically similar.
Has anybody checked whether PEA lowers the blood pressure? This is very important for low-blood pressure glaucoma patients to know.