10 days ago

Jo Ann • 160

@jo_ann_87

My Dr. has recommended the eye injection, Durysta. I'm really hesitant. He indicated that since the injection is localized in the eye, there's less chance of side effects. However, upon researching this procedure and drug, there are serious side effects that to me, seem to outweigh the possible benefits.

Again, this is the glaucoma patients dillema! The side effects include headache, fatigue, infections, etc, etc. I had horrible on Latanaprost, a prostoglandin, and Durysta is a prostoglanidn.

Have any of you had a good experience(if that's ever possilbe with glaucoma remedies)?

I'd also be interested to know the side effects any of you may have experienced. Thanks in advance for your replies. Jo Ann

10 days ago

david 4.3k

@david_fe

You are right to be concerned, given that you "had horrible on Latanaprost, a prostoglandin, and Durysta is a prostoglanidn."

Which specific symptoms did you have on Latanoprost?

Prostaglandin analogs, including Latanoprost, Bimatoprost, Travoprost, and Tafluprost, share similar mechanisms of action and similar side effect profiles. Common side effects include conjunctival hyperemia, eyelash changes, and increased iris pigmentation.[1-6]

A meta-analysis by Tang et al. found that Bimatoprost had a higher incidence of conjunctival hyperemia compared to Latanoprost and Travoprost, indicating that some prostaglandin analogs may have a higher likelihood of causing certain side effects.[1] Similarly, Lin et al. reported that Latanoprost had the most favorable tolerability profile among the prostaglandin analogs, with Bimatoprost associated with the highest risk of hyperemia.[2]

Note that Durysta is bimatoprost.

However, individual responses can vary, and some patients may tolerate one prostaglandin analog better than another. For example, Travoprost, which is preserved with sofZia, may be better tolerated in some patients compared to those preserved with benzalkonium chloride (BAK).[4-5]

In summary, while there is a significant probability of experiencing similar side effects with other prostaglandin analogs, the specific tolerability can vary between individuals. But with drops, you can stop using them if you have side effects. With a Durysta injection, you can't easily make it stop releasing the bimatoprost.

The intracameral Durysta (bimatoprost) implant cannot be removed once it has been administered. The implant is designed to be biodegradable and gradually releases the medication over time. If a patient experiences intolerable side effects, there is not really a good solution IMO.

Personally, if my experience was poor on Latanoprost, I would not risk the Durysta injection. But that's just me.

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